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Using low-dose atropine in control of intermittent exotropia
Farzaneh Dehghanian Nasrabadi1, Ali Mirzajani1, Mostafa Soltan Sanjari2
1Rehabilitation Research Center, Department of Optometry, Iran University of Medical Sciences, Tehran, Iran.
Clinical & Experimental Optometry
|February 24, 2026
Summary
Low-dose atropine eye drops effectively control intermittent exotropia in children, showing similar results to overminus lenses. This makes 0.05% atropine a viable alternative treatment option for managing this condition.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Strabismus Management
Background:
- Intermittent exotropia requires effective non-surgical management strategies.
- Identifying treatments with minimal risk and side effects is crucial for patient care.
Purpose of the Study:
- To evaluate the efficacy of 0.05% atropine eye drops for controlling intermittent exotropia in children.
- To compare the effectiveness of low-dose atropine with overminus lenses.
Main Methods:
- A randomized clinical trial involving children aged 2-8 years with intermittent exotropia.
- Participants were assigned to either 0.05% atropine or overminus lenses for 3 months.
- Deviation control was assessed using 3-point and 6-point scales.
Main Results:
- Both 0.05% atropine and overminus lenses significantly improved deviation control at 1 and 3 months post-intervention.
- Improvements in distance and near deviation control were observed in both groups over the 3-month period.
- Low-dose atropine demonstrated significant improvements in near deviation control at 3 months compared to 1 month.
Conclusions:
- 0.05% atropine eye drops are effective in controlling intermittent exotropia in children.
- Low-dose atropine shows comparable effectiveness to overminus lenses.
- Atropine presents a potentially efficient alternative treatment for intermittent exotropia.
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