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Updated: Apr 9, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Visual outcomes following implantation of intracorneal rings with sharp and round triangular cross-section designs in
Somaye Soleimani1,2, Shiva Pirhadi3,4, Khosrow Jadidi3
1School of Optometry, University of Montreal, Montreal, Canada.
Purpose:
To compare the visual, refractive, corneal curvature, and aberrometry outcomes one year following implantation of two intra-stromal corneal rings (ICRS) with different cross-sectional designs.
Methods:
This retrospective longitudinal study included 40 keratoconus eyes implanted with ICRSs with similar characteristics except for their cross-sectional design, Keraring with sharp corners triangular cross-section (n = 20 eyes) and Keratacx Plus with round corners triangular cross-section (n = 20 eyes). The two rings were similar in terms of arc length (355°) and outer diameter (5.7 mm). The uncorrected and corrected distance visual acuity (UDVA & CDVA), refraction, corneal topography, and aberrometry indices were compared before and one year after surgery.
Results:
Despite a significant change in VA, spherical equivalent, astigmatism, and keratometry readings, there was no statistically significant difference in their mean changes between the two rings. (P > 0.05) The mean corneal asphericity expressed by the Q-value showed a statistically significant change toward less prolateness after surgery and was the only parameter with a significant mean change between the two groups (P = 0.04). In comparing the mean changes of corneal aberrometry indices between two rings, a statistically significant difference was seen for total aberration (P = 0.03), lower order aberrations (LOA, P = 0.03), and defocus (P = 0.03). Subgroup analysis based on keratoconus severity (mild and moderate stages) showed a statistically significant difference in Q-value (P = 0.019), total aberration (P = 0.040), LOA (P = 0.041), and defocus (P = 0.027) only for the moderate keratoconus group between the two rings.
Conclusions:
Both rings provided a significant improvement in visual, refractive, and keratometric parameters so that the triangular cross-sectional design of Keratacx Plus with round corners is not superior to Keraring with sharp corners in terms of visual quality and higher order aberrations (HOAs).

