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Updated: Feb 26, 2026

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
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PKM2-DNMT3A-SMAD2 Axis Regulates Cell Proliferation via Histone Lactylation in Breast Cancer

Abin Sabu1, Deepak Pant1, Srinivas Abhishek Mutnuru1

  • 1Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India.

Molecular and Cellular Biology
|February 25, 2026
PubMed
Summary

Lactate, a cancer cell byproduct, influences gene expression through histone lactylation. This study reveals how this metabolic-epigenetic process drives breast cancer progression by regulating key genes and pathways.

Keywords:
Histone lactylationPKM2breast cancercancer metabolismepigenetics

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