Research progress on the correlation between blood pressure variability and hypertensive microvascular disease

Area of Science:

• Cardiovascular Medicine
• Nephrology
• Neurology

Background:

• Hypertensive microvascular disorder causes significant target organ damage, including cognitive, visual, and renal impairments.
• Blood pressure variability (BPV) is increasingly recognized as an independent risk factor for this pathology's progression.

Purpose of the Study:

• To systematically review the concept, classification, and clinical significance of BPV.
• To elucidate BPV's role as a pathogenic mechanism independent of mean blood pressure in exacerbating endothelial injury and organ damage.

Main Methods:

• Systematic literature review evaluating factors influencing BPV.
• Analysis of neurohumoral regulation, behavioral environment, and comorbidities' impact on BPV.
• Emphasis on the link between BPV and microvascular complications in specific populations.

Main Results:

• BPV acts as an independent pathogenic mechanism contributing to target organ damage.
• Factors such as neurohumoral regulation, environment, and comorbidities influence BPV.
• A strong association exists between BPV and microvascular complications, particularly in diabetes and obesity.

Conclusions:

• Comprehensive understanding of BPV mechanisms is crucial for early prevention and treatment.
• BPV is a critical factor in hypertensive microvascular disease progression.
• Targeting BPV may offer new therapeutic strategies for organ protection.