Recent Advances in Nanozymes Toward Diabetic Foot Ulcers

Area of Science:

• Biomaterials Science
• Nanotechnology
• Regenerative Medicine

Background:

• Diabetic foot ulcers (DFUs) are severe diabetes complications with poor healing due to oxidative stress and inflammation.
• Conventional treatments fail to optimize the wound microenvironment, leading to slow healing and recurrence.

Purpose of the Study:

• To review recent advances in nanozyme applications for managing diabetic foot ulcers.
• To highlight nanozymes' catalytic mechanisms and therapeutic potential in remodeling the DFU microenvironment.

Main Methods:

• Discussion of nanozymes mimicking natural enzymes (e.g., oxidase, peroxidase, catalase, SOD).
• Focus on nanozyme strategies including microenvironment-responsive systems, hydrogel composites, and synergistic platforms.
• Analysis of catalytic mechanisms and therapeutic applications for DFU management.

Main Results:

• Nanozymes actively remodel the DFU microenvironment through glucose depletion, ROS regulation, biofilm disruption, and oxygen generation.
• Integrated nanozyme functions promote faster wound healing, angiogenesis, and tissue regeneration.
• Review of advanced nanozyme platforms for enhanced DFU therapy.

Conclusions:

• Nanozymes present a promising strategy for DFU treatment by addressing key pathological factors.
• Further research is needed on biosafety, efficiency, and target accuracy for clinical translation.
• Nanozymes hold potential for improved DFU management and patient outcomes.