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Bloodstream Infections Among Veterans With Cardiac Implantable Electronic Devices: Source Identification and

Dipandita Basnet1,2, Samuel Golenbock1, Judith M Strymish3,4

  • 1Center for Health Optimization and Implementation Research (CHOIR), VA Boston Healthcare System, Boston, Massachusetts, USA.

Open Forum Infectious Diseases
|February 25, 2026
PubMed

Insights

Bloodstream infections are common in patients with cardiovascular implantable electronic devices (CIEDs). Factors like other device infections and endocarditis increase CIED involvement risk, while urinary tract infections decrease it.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Devices

Background:

  • Bloodstream infections are a significant concern in patients with cardiovascular implantable electronic devices (CIEDs).
  • Understanding the incidence and risk factors for CIED involvement in bacteremia is crucial for patient management.

Purpose of the Study:

  • To determine the incidence of bacteremia in veterans with CIEDs.
  • To identify factors associated with CIED involvement in cases of bacteremia.

Main Methods:

  • Retrospective analysis of veteran data from 2018 to 2023.
  • Identification of patients with bloodstream infections and CIEDs.
  • Statistical analysis to determine risk factors for CIED involvement.

Main Results:

  • 4.7% of veterans with CIEDs developed bacteremia (1893/40,243).
  • CIED involvement was identified in 305 patients.
  • Increased risk of CIED involvement was linked to prior device infections and endocarditis.
  • Urinary tract infection was associated with a decreased risk of CIED involvement.

Conclusions:

  • Bacteremia is a notable complication in veterans with CIEDs.
  • Specific comorbidities like endocarditis increase the risk of CIED infection.
  • Urinary tract infections may have a protective effect against CIED involvement during bacteremia.

Keywords:
bloodstream infectioncardiovascular deviceinfection surveillance and stewardship

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