Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease

This study examined whether performance on the web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME), an associative memory test, is associated with plasma biomarkers in autosomal dominant Alzheimer's disease (ADAD).

One hundred sixty-one members from the Colombian kindred with presenilin-1 (PSEN1) E280A mutation (61 cognitively unimpaired carriers, 22 cognitively impaired carriers, and 78 non-carriers), completed the web-based LAS-FNAME and provided blood samples for biomarker analysis. Analysis of covariance was used to compare LAS-FNAME performance among groups and Spearman correlations to examine its associations with levels of plasma phosphorylated tau (p-tau)217, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP).

Carriers had lower LAS-FNAME performance (P < 0.001) and higher p-tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non-carriers. Higher p-tau217, NfL, and GFAP were associated with worse LAS-FNAME performance, controlling for age, sex, and education.

The web-based LAS-FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility.

The web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME) detects memory decline in presenilin 1 (PSEN1) mutation carriers.LAS-FNAME scores correlate with blood biomarkers in PSEN1 carriers.The web-based format enables remote assessment via participants' personal devices.The study was conducted in Spanish-speaking adults at risk for dementia.Findings support combined use of digital cognitive tools and blood biomarkers.