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Updated: Feb 26, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Rickets and Metastatic Mineralization in Broilers Associated with Excess Dietary Calcium and Phosphorous
Peter M O'Kane1, Allan R Ball2, Carlo Bianco3
1Slate Hall Veterinary Services, Moorlands Trading Estate, Lincoln LN4 3HX, United Kingdom, petermokane@yahoo.co.uk.
Early-onset rickets and visceral mineralization in broilers were linked to excessive dietary calcium and phosphorus. This nutritional imbalance caused severe lameness, poor growth, and high mortality rates in young chickens.
Area of Science:
- Avian pathology
- Poultry nutrition
- Veterinary medicine
Background:
- Elevated mortality and culling observed in 7-day-old UK broilers.
- Clinical signs included weakness, lameness, and wet litter.
Purpose of the Study:
- Investigate the cause of early-onset lameness and mortality in broilers.
- Determine the underlying pathology and contributing nutritional factors.
Main Methods:
- Necropsy and histopathology of affected chicks.
- Bacteriologic examination of samples.
- Feed analysis of starter ration.
Main Results:
- Histopathology revealed tibial dyschondroplasia and osteodystrophy.
- Mineralization identified in gizzard, kidneys, and proventriculus.
- Feed analysis showed excessive calcium and phosphorus levels, with an imbalanced ratio.
Conclusions:
- The case presented as early rickets with metastatic visceral mineralization.
- Nutritional imbalance in the starter ration was the primary cause.
- High mortality and culling rates were associated with these findings.
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