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Updated: Feb 26, 2026

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Comparative 18 F-FDG PET/CT and FAP-targeted PET/CT Findings in Parotid Warthin Tumor
Ke Cheng1,2,3, Tingting Xu1,2,3, Peng Wang1,2,3
1Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University.
Abstract:
Warthin tumor is the second most common benign parotid neoplasm and often shows marked uptake on 18 F-FDG PET/CT, frequently mimicking malignancy. In contrast, its imaging characteristics on fibroblast activation protein (FAP)-targeted PET/CT remain insufficiently defined. We report 2 cases of parotid Warthin tumors that demonstrated marked FDG uptake but absent or minimal uptake on FAP-targeted PET/CT using 68 Ga-FAPI-04 and 68 Ga-FAP-2286. This discordant imaging pattern suggests that FAP-targeted PET/CT may aid in distinguishing Warthin tumor from malignant lesions.
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