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Updated: Feb 28, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
Shifting metabolism alters rRNA expression in malaria parasites
Evi Hadjimichael1, Kirk W Deitsch1
1Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
None:
Malaria parasites display the unique property of expressing distinct ribosomal RNAs at different points in their transmission cycle. Couble et al. determined that derepression of the mosquito-specific rDNA loci is initiated by altered NAD+/nicotinamide (NAM) ratios, resulting from the metabolic shift that parasites undergo as they transition into the mosquito stages.
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