DNA-based hybrid nanoparticles: from design to application in cancer therapy

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Oncology

Background:

• Deoxyribonucleic acid (DNA)-based hybrid nanoparticles integrate functional components with DNA scaffolds.
• These systems leverage DNA's programmability and biocompatibility with the unique properties of inorganic/organic materials.

Purpose of the Study:

• To systematically review DNA-based hybrid nanoparticles for oncology applications.
• To highlight their advantages, therapeutic potential, and challenges for clinical translation.

Main Methods:

• Review of hybrid strategies and characteristics of DNA-based hybrid nanoparticles.
• Survey of therapeutic applications in cancer treatment and diagnosis.

Main Results:

• DNA-based hybrid nanoparticles offer multifunctionality beyond single-component platforms.
• Key advantages in oncology include gene editing, physical energy-activated therapies, immunotherapy, and theranostics.

Conclusions:

• DNA-based hybrid nanoparticles show significant therapeutic potential in cancer.
• Future directions involve intelligent design, scalable manufacturing, and safety evaluation for clinical translation.