Related Experiment Video

Updated: Feb 27, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
07:35

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

43.0K

Influence of Hypertension Management on Survival in Patients With Metastatic Breast Cancer

Reina Haque1,2, Amrita Mukherjee1, Lie Hong Chen1

  • 1Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.

Cancer Medicine
|February 26, 2026
PubMed

Insights

Managing hypertension with multiple medications (polytherapy) significantly lowers mortality risk in women with metastatic breast cancer (mBC). This survival benefit was most pronounced in Hispanic women, highlighting the importance of comprehensive comorbidity management for improved outcomes.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Hypertension is prevalent in nearly half of women with metastatic breast cancer (mBC).
  • The impact of hypertension management on survival outcomes in mBC patients remains under investigation.
  • This study addresses the critical question of whether pharmacologic hypertension management influences mortality in mBC.

Purpose of the Study:

  • To investigate the association between antihypertensive medication use and mortality in patients with metastatic breast cancer.
  • To compare the effects of antihypertensive monotherapy versus polytherapy on all-cause and breast cancer-specific mortality.
  • To explore potential disparities in treatment effects across different racial and ethnic groups.

Main Methods:

  • A longitudinal cohort study included 1332 female patients with de novo mBC diagnosed between 2008 and 2020.
  • Data were collected through 2021, with person-year rates calculated for mortality outcomes.
  • Multivariable Cox regression models were employed to analyze the relationship between antihypertensive use (monotherapy vs. polytherapy) and mortality risk.

Main Results:

  • Over half of mBC patients (52.9%) received antihypertensive treatment, with polytherapy used by 32.5%.
  • All-cause mortality risk was 38% lower in the polytherapy group compared to the monotherapy group (aHR=0.62).
  • Significant risk reduction was observed in Hispanic patients (aHR=0.40) and suggested in Black patients (aHR=0.48); breast cancer mortality also decreased with polytherapy, especially with good adherence.

Conclusions:

  • Antihypertensive polytherapy is associated with reduced all-cause mortality risk in mBC patients compared to monotherapy.
  • The survival benefit of polytherapy was most substantial among Hispanic women.
  • Further research is warranted to optimize comorbidity management strategies for extending life in mBC patients, particularly women of color.
Abstract

Keywords:
antihypertensivescomorbiditiesdisparitieshypertensionmetastatic breast cancermortalitysurvival

More Related Videos

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

3.9K
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K

Related Concept Videos

Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
544
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
797
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.3K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
419
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
7.4K
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
1.0K