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Related Experiment Video

Updated: Feb 27, 2026

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Dentinal Grafts, a Promising Material for Alveolar Defects: A Systematic Review and Meta-Analysis.

Syed Kowsar Ahamed1, Saverio Cosola2,3, Ali Abdullah Alqarni1

  • 1Faculty of Dentistry, Taif University, Taif 21944, Saudi Arabia.

Dentistry Journal
|February 26, 2026
PubMed
Summary

Dentinal grafts are a promising bone grafting material for preserving alveolar bone after tooth extraction, showing better bone formation and resorption than xenografts. These grafts offer comparable implant success rates and significantly reduce bone loss compared to natural healing.

Keywords:
alveolar ridge augmentationalveolar ridge preservationautogenous tooth graftautograftsbone regenerationdentindentin graft

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Area of Science:

  • Dental surgery
  • Biomaterials science
  • Regenerative medicine

Background:

  • Alveolar ridge preservation is crucial for dental implant success.
  • Dentinal grafts are emerging as a popular autogenous bone grafting material.
  • They offer potential advantages in biocompatibility and cost over traditional xenografts.

Purpose of the Study:

  • To compare dentinal grafts with xenografts and natural blood clots for socket healing.
  • To evaluate their efficacy in maintaining bone quality and quantity for implant success.
  • To assess their performance against other bone graft materials.

Main Methods:

  • Systematic search of multiple databases (PubMed/MEDLINE, Scopus, Cochrane, Embase, Google Scholar) from 2015-2025.
  • Inclusion of randomized controlled trials only.
  • Quality assessment using Cochrane Risk of Bias 2 tool and meta-analysis.

Main Results:

  • Dentinal grafts significantly increased new bone formation (12.4% greater than xenografts) and resorbed more completely.
  • Implants in dentinal graft sites showed comparable stability and success rates to xenografts.
  • Dentinal grafts dramatically reduced bone loss (60-75%) compared to natural healing, with minimal complications (2.2%).

Conclusions:

  • Dentinal grafts are a viable and potentially superior alternative to xenografts for alveolar bone preservation and bone defects.
  • Partially demineralized dentinal preparations are particularly supported by evidence.
  • These grafts exhibit excellent biocompatibility, promote good bone quality, and are cost-effective.