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Fermented Plant Extract-Loaded Collagen Scaffolds: Bioactive Hydrogels for Enhanced Wound Repair and Immune

Lesly Katleya Usme-Duque1,2, Miguel A Medina-Morales1, María I León-Campos2

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Summary

Collagen hydrogels loaded with Flourensia cernua extracts show potential for tissue regeneration. These bioactive matrices enhance cell activity and promote wound healing, offering a promising scaffold for regenerative medicine applications.

Keywords:
Flourensia cernua extractcollagen hydrogelscontrolled releasepolyphenolstissue regenerationwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Natural Product Chemistry

Background:

  • Flourensia cernua (F. cernua) extracts contain polyphenols with tissue regeneration potential.
  • Controlled delivery systems are needed to improve the bioavailability and efficacy of F. cernua extracts.
  • Collagen hydrogels offer a suitable matrix for encapsulating bioactive compounds.

Purpose of the Study:

  • To develop and characterize collagen hydrogels loaded with F. cernua extracts for sustained release.
  • To evaluate the physicochemical, mechanical, and biological properties of these bioactive matrices.
  • To assess the potential of F. cernua-loaded hydrogels for wound healing and tissue regeneration.

Main Methods:

  • Encapsulation of F. cernua extracts (7-21 wt.%) in collagen hydrogels.
  • Assessment of extract release kinetics, hydration, crosslinking, and gelation.
  • Characterization using SEM, mechanical testing, and biodegradation studies.
  • Evaluation of hemocompatibility, cell metabolic activity, proliferation, and anti-inflammatory effects (TNF-α secretion).
  • In vitro wound closure assays using fibroblast cultures.

Main Results:

  • Sustained release of F. cernua extract from hydrogels was achieved, particularly at 14 wt.% concentration.
  • Increased extract concentration enhanced hydration and crosslinking density, improving thermal stability.
  • Hydrogels exhibited slow degradation and were hemocompatible.
  • 14 wt.% extract-loaded hydrogels significantly boosted monocyte and fibroblast activity and proliferation.
  • 7 wt.% extract demonstrated anti-inflammatory potential by reducing TNF-α secretion.
  • Significant wound closure (90% contraction in 10 days) was observed in vitro.

Conclusions:

  • F. cernua-enriched collagen hydrogels are effective bioactive matrices with sustained release properties.
  • These hydrogels promote cell proliferation, exhibit anti-inflammatory effects, and enhance wound closure.
  • The developed scaffolds show significant promise for applications in wound healing and tissue regeneration.