Association Between ADA (Age-D-dimer-Albumin) Score and Chest CT Severity Score in COVID-19 Pneumonia

Area of Science:

• Pulmonology
• Radiology
• Infectious Diseases

Background:

• COVID-19-related severe acute pneumonia requires accurate severity assessment.
• Chest tomography (CT) is crucial for evaluating pneumonia extent.
• The ADA score's relationship with pneumonia severity and CT findings needs clarification.

Purpose of the Study:

• To assess the correlation between the ADA score and pneumonia severity determined by CT.
• To evaluate the ADA score's predictive value for intensive care unit (ICU) admission.
• To explore the association of the ADA score with CT Severity Score (CTSS), GFR, and CRP.

Main Methods:

• Observational study of 350 hospitalized COVID-19 patients with severe pneumonia.
• High-resolution chest computed tomography (HRCT) performed for all patients.
• Calculation of ADA score and semi-quantitative 25-point CT Severity Score (CTSS).

Main Results:

• CTSS was statistically associated with the ADA score (p=0.009) and ICU need (p<0.001).
• Linear regression showed CTSS relates to ADA score, GFR, and CRP (p=0.003).
• Optimal ADA score cut-off of 44.5 predicted severe CT findings (AUC: 0.750, p<0.001).

Conclusions:

• The ADA score is a valuable tool for assessing COVID-19 pneumonia severity.
• Integrating ADA score with CT findings improves patient risk stratification.
• Combined assessment aids in early identification of high-risk patients with extensive pulmonary involvement.