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Updated: Feb 27, 2026

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Patient-Controlled Analgesia in ICU: A Scoping Review
Angela Califano1, Riccardo Caldonazzo1, Miriam Gotti2
1School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milano, Italy.
Journal of Personalized Medicine
|February 26, 2026
Summary
Patient-Controlled Analgesia (PCA) offers personalized pain management in the Intensive Care Unit (ICU). While feasible and safe for post-cardiac surgery patients, more standardized research is needed to define its broader ICU role.
Area of Science:
- Critical Care Medicine
- Pain Management
- Evidence Synthesis
Background:
- Patient-Controlled Analgesia (PCA) is established for postoperative pain but lacks clear definition and standardization in Intensive Care Units (ICUs).
- Existing PCA use in ICUs is fragmented, necessitating a comprehensive overview of current evidence.
Purpose of the Study:
- To conduct a scoping review mapping the evidence on PCA use in ICU patients.
- To identify uncertainties and knowledge gaps regarding PCA in the ICU setting.
Main Methods:
- Scoping review methodology adhering to PRISMA-ScR guidelines.
- Systematic identification and synthesis of relevant studies on PCA in ICUs.
Main Results:
- 12 studies were included, suggesting PCA provides comparable pain control to traditional methods in post-cardiac surgery ICU patients.
- Evidence for PCA in non-surgical ICU patients is limited.
- PCA demonstrated good feasibility and a favorable safety profile with low respiratory events due to intensive monitoring.
- Significant methodological variability across studies hinders direct comparisons.
Conclusions:
- PCA facilitates personalized pain management tailored to individual patient needs and responses in critical care.
- Further standardized research is essential to establish definitive guidelines for PCA implementation in ICUs.
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