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Related Concept Videos

Multicompartment Models: Overview01:14

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Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
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Related Experiment Videos

A Cross-Domain Benchmark of Intrinsic and Post Hoc Explainability for 3D Deep Learning Models.

Asmita Chakraborty1, Gizem Karagoz1, Nirvana Meratnia1

  • 1Department of Mathematics and Computer Science, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands.

Journal of Imaging
|February 26, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a unified framework for benchmarking explainable AI (XAI) in 3D data. Results show no single XAI method excels across all domains, emphasizing the need for domain-specific evaluation.

Keywords:
3D deep learning3D medical imaging3D point cloud analysisbenchmarking frameworkexplainable artificial intelligence (XAI)intrinsic explainabilitypost hoc explainabilityquantitative evaluationvoxelized data

Related Experiment Videos

Area of Science:

  • Artificial Intelligence
  • Computer Vision
  • Medical Imaging

Background:

  • Deep learning for 3D data is prevalent in medical imaging, object recognition, and robotics.
  • The increasing use of AI necessitates explainability due to the black-box nature of models.
  • Lack of standardized benchmarks hinders reliable comparison of explainable AI (XAI) methods for 3D data.

Purpose of the Study:

  • To present a unified benchmarking framework for evaluating intrinsic and post hoc XAI methods on diverse 3D datasets.
  • To quantitatively assess the performance of various XAI techniques across medical CT scans, CAD models, and point clouds.
  • To provide comparative insights for selecting appropriate XAI methods in different 3D data domains.

Main Methods:

  • Developed a unified benchmarking framework for 3D explainability.
  • Evaluated XAI methods (Grad-CAM, Integrated Gradients, Saliency, Occlusion, ResAttNet-3D) on CT scans (MosMed), CAD models (ModelNet40), and point clouds (ScanObjectNN).
  • Assessed explanation quality using Correctness (AOPC), Completeness (AUPC), and Compactness metrics.

Main Results:

  • Explanation quality varied significantly across methods and domains.
  • Grad-CAM and intrinsic attention performed best on medical CT scans.
  • Gradient-based methods showed superior performance on voxelized and point-based data.
  • Statistical tests confirmed significant performance differences among methods.

Conclusions:

  • No single XAI method is universally superior across all 3D data domains.
  • Domain-specific evaluation and multi-metric assessment are crucial for selecting effective XAI techniques.
  • The proposed framework enables reproducible and standardized assessment of 3D explainability.