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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 17, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
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Tooth Root-Derived Graft Promotes Complete Bone Replacement in Alveolar Ridge Preservation: Comparative Study with a

Yasushi Nakajima1,2, Takahisa Iida1,2, Elio Minetti3

  • 1Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.

Journal of Functional Biomaterials
|February 26, 2026
PubMed
Summary

Tooth-derived grafts showed superior bone regeneration with minimal remnants compared to xenografts in alveolar ridge preservation. This suggests tooth grafts may offer better outcomes for future dental implant placement.

Keywords:
alveolar ridge augmentationbone regenerationbone substitutesdentindogshistological techniquestooth extractionxenografts

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral Surgery

Background:

  • Autogenous tooth-derived grafts are explored as alternatives to xenografts for alveolar ridge preservation.
  • These grafts offer biological similarity to bone and potentially better remodeling outcomes.
  • This study compares a collagenated xenograft with a tooth-derived graft processed via an automated device.

Purpose of the Study:

  • To compare the healing outcomes of tooth-derived grafts versus collagenated xenografts in alveolar ridge preservation.
  • To evaluate crestal dimensions, bone maturity, residual graft material, and soft tissue healing.
  • To assess the potential implications for subsequent dental implant placement.

Main Methods:

  • Bilateral mandibular premolar extractions were performed in six Beagle dogs.
  • Sockets were grafted with either automated device-processed tooth-derived particulate or a collagenated xenograft, both covered by a collagen membrane.
  • Histological analysis was conducted after 3 months to assess bone and graft characteristics.

Main Results:

  • Tooth-derived grafts resulted in significantly less residual material (0.5%) and a higher proportion of bone (65.6%) compared to xenografts (19.7% residual material).
  • Buccal crest height was slightly greater with xenografts, but lingual crest height did not differ.
  • Corticalization at the socket entrance was more prevalent with tooth-derived grafts, with no observed inflammation.

Conclusions:

  • Tooth-derived grafts facilitate near-complete replacement by vital bone with minimal residual particles.
  • Xenografts offered slightly better buccal contour but contained persistent graft particles.
  • Observed biological differences highlight potential advantages of tooth-derived grafts for future implant procedures.