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A Real-World Data Analysis on Feline Chronic Kidney Disease in Greece: Clinical Profiles, Comorbidities, and Quality

Ioulia Chortara1, Irene Chatzipanagiotidou1,2, Ioli Moutsopoulou1,2

  • 1Asclepius One Health Platform, 10671 Athens, Greece.

Veterinary Sciences
|February 26, 2026
PubMed

Insights

Feline chronic kidney disease (fCKD) significantly impacts geriatric cats. Managing comorbidities like anemia and dental disease alongside fCKD is crucial for improving feline quality of life.

Area of Science:

  • Veterinary Medicine
  • Animal Health
  • Nephrology

Background:

  • Feline chronic kidney disease (fCKD) is highly prevalent in older cats, posing diagnostic challenges.
  • It is a significant cause of illness and mortality in domestic cats.

Purpose of the Study:

  • To characterize clinical profiles, comorbidities, and quality of life in cats with fCKD in Greece.
  • To assess the impact of comorbidities and disease stage on feline health-related quality of life (HRQL).

Main Methods:

  • Analysis of real-world data from 208 client-owned cats with fCKD.
  • Assessment of clinical findings, body/muscle condition, IRIS staging, and owner-completed HRQL questionnaires (VetMetrica™).
  • Statistical analysis to determine associations between comorbidities, IRIS stage, and HRQL domains.

Main Results:

  • Comorbidities were present in 66.8% of cats; oral/dental disease (29.81%) and anemia (15.38%) were most common.
  • HRQL scores significantly declined with advancing IRIS stage (p < 0.001).
  • Anemia strongly correlated with reduced HRQL (18.79-point drop in Emotional Wellbeing, p < 0.001); oral disease also impacted Comfort and Emotional Wellbeing.

Conclusions:

  • Comorbidities independently contribute to impaired quality of life in cats with fCKD.
  • Early detection and management of fCKD and its associated comorbidities are vital for enhancing feline welfare.
  • Targeted management of conditions like anemia and dental disease can significantly improve patient outcomes.

Keywords:
Greececatchronic kidney diseasequality of lifereal-world data

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