Mesoporous Bioactive Glass: Preparation, Characterisation, and Emerging Applications in Regenerative Medicine and...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Dental Materials

Background:

• Mesoporous bioactive glasses (MBGs) possess unique properties like ordered mesoporous structures, large surface areas, and enhanced bioactivity.
• These characteristics differentiate MBGs from conventional bioactive glasses, driving interest in regenerative medicine and dentistry.

Purpose of the Study:

• To review the development, synthesis, structural characteristics, and applications of MBGs.
• To focus on the translational potential of MBGs in clinical settings.

Main Methods:

• A narrative literature review was performed using major scientific databases.
• Peer-reviewed studies on MBG preparation, characterization, and applications were critically analyzed.

Main Results:

• MBGs exhibit tunable pore sizes, high surface area, and controlled ion/drug release, promoting hydroxyapatite formation and cell proliferation.
• Synthesis methods like sol-gel and templating allow precise control over MBG composition and mesostructure.
• Applications span bone/soft tissue regeneration, drug delivery, wound healing, and various dental treatments, though most evidence is pre-clinical.

Conclusions:

• MBGs are promising biomaterials for regenerative and dental applications due to enhanced bioactivity and therapeutic delivery.
• Limitations in mechanical strength, scalability, and clinical data hinder current widespread application.
• Addressing translational challenges is key to realizing the full potential of MBGs in improving regenerative and restorative dental outcomes.