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Multicenter validation of AI-enabled ECG for pediatric biological sex prediction

Donnchadh O'Sullivan1, Joshua Mayourian2, Scott Anjewierden3

  • 1Department of Pediatrics, Division of Pediatric Cardiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA. donnchadhosull@gmail.com.

NPJ Digital Medicine
|February 26, 2026
PubMed

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The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...