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Published on: December 9, 2016
SASdb: a comprehensive database for sex-biased alternative splicing profiles in human tissues
Xi Chen1, Yueqi Lu2, You Duan3
1Department of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
This study introduces SASdb, a database of sex-biased alternative splicing (SAS) events across human tissues. SASdb reveals molecular sex differences and highlights SAS events in cancer, aiding precision medicine research.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Alternative splicing (AS) increases transcriptomic diversity.
- AS dysregulation is linked to human diseases.
- No comprehensive database exists for sex-related AS events across human tissues.
Purpose of the Study:
- To develop SASdb, a public database for sex-related alternative splicing (SAS) events.
- To analyze sex-specific splicing patterns and their implications.
- To support research in sex biology and precision medicine.
Main Methods:
- Development of the SASdb database.
- Compilation of 2,951,059 AS events and 46,418 SAS events.
- Analysis of SAS events across 22 human tissues.
- Case study on non-small cell lung cancer (NSCLC) SAS events.
Main Results:
- SASdb provides a comprehensive resource for sex-related AS events.
- Extensive sex-specific splicing patterns were identified.
- NSCLC-specific SAS events were found to be enriched in cancer-related pathways.
Conclusions:
- SASdb offers novel insights into molecular sex differences.
- The database can facilitate research into sex biology and precision medicine.
- SASdb highlights the role of sex-biased splicing in diseases like NSCLC.
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