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Updated: May 6, 2026

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The Measurement and Treatment of Suppression in Amblyopia
Published on: December 14, 2012
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Video Game-Based Interventions for Visual Rehabilitation in Childhood Amblyopia: A Systematic Review and
Marina Piñar-Lara1,2, Esteban Obrero-Gaitán2, Sara Gómez-Molina3
1CAIT APROMPSI, C/Clara Campoamor 8, 23470 Cazorla, Spain.
Children (Basel, Switzerland)
|February 27, 2026
Summary
Video game-based interventions (VGBIs) effectively improve visual acuity (VA) in children with amblyopia. This approach is more effective than patching therapy, especially when used in combination.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Digital Therapeutics
Background:
- Amblyopia, or "lazy eye," significantly impacts visual development in children.
- Traditional amblyopia treatments have limitations in adherence and effectiveness.
- Novel approaches like video games offer potential for engaging pediatric amblyopia therapy.
Purpose of the Study:
- To determine the efficacy of video game-based interventions (VGBIs) for improving visual acuity (VA) in children with amblyopia.
- To assess the safety, satisfaction, and compliance associated with VGBIs.
- To compare VGBIs with traditional treatments like patching therapy.
Main Methods:
- A systematic review with meta-analysis (SRMA) adhering to PRISMA guidelines.
- Inclusion of randomized controlled trials (RCTs) and pilot RCTs without date or language restrictions.
- Pooled effect estimation using Cohen's standardized mean difference (SMD) and 95% confidence intervals (95%CI).
Main Results:
- Twenty-one RCTs involving 1515 children demonstrated that VGBIs are effective in increasing VA (SMD = 0.38; p = 0.013).
- Non-immersive video games showed particular promise for VA improvement (SMD = 0.35; p = 0.039).
- VGBIs proved more effective than patching therapy, especially when combined (SMD = 0.63; p < 0.001).
Conclusions:
- Video game-based interventions represent a statistically significant and effective treatment for amblyopia in children.
- VGBIs offer a promising alternative or adjunct to traditional amblyopia therapies.
- Further research into optimizing VGBI protocols for different amblyopia types is warranted.
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