Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.5K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.5K
Inflammatory Response01:28

Inflammatory Response

17.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.5K
Inflammation01:38

Inflammation

62.8K
Overview
62.8K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of <i>Typha angustifilia</i> Fiber-Matrix Bonding Parameters on Interfacial Shear Strength Analysis.

Polymers·2022
Same author

Mechanical Ventilator Parameter Estimation for Lung Health through Machine Learning.

Bioengineering (Basel, Switzerland)·2021
Same author

Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model.

Neural regeneration research·2020
Same author

Physiochemical Effects of Nanoparticles on Cell Nuclear Complex Pore Transport: A Coarse-Grained Computational Model.

Journal of chemical theory and computation·2019
Same author

Influence of Pathogens and Mechanical Stimuli in Inflammation.

Bioengineering (Basel, Switzerland)·2019
Same author

An integrated parametric model for MT self-assembly formation analysis.

Bio Systems·2018
Same journal

Correction: Komatsu et al. Three-Dimensional Visualization and Detection of the Pulmonary Venous-Left Atrium Connection Using Artificial Intelligence in Fetal Cardiac Ultrasound Screening. <i>Bioengineering</i> 2026, <i>13</i>, 100.

Bioengineering (Basel, Switzerland)·2026
Same journal

Comparison of CO<sub>2</sub> Laser and Microdebrider in the Surgical Treatment of Pediatric Recurrent Respiratory Papillomatosis: A Retrospective Analysis.

Bioengineering (Basel, Switzerland)·2026
Same journal

Toward More Translational Tumor Models: Breast dECM-Based 3D Systems Capture Native Microenvironmental Cues.

Bioengineering (Basel, Switzerland)·2026
Same journal

Postural Stability Changes During the 4 Phases of the Half Squat: Kinematics Profile of the Center of Pressure and Center of Mass in High-Performance Weightlifters-A Pilot Study.

Bioengineering (Basel, Switzerland)·2026
Same journal

Definite Implant Position as Novel Readout for Effectiveness of Ridge Preservation Indicates to Beneficial Effect of Combined Treatment with Platelet-Rich Fibrin (PRF) and Xenogenic Biomaterial in Bone Regeneration.

Bioengineering (Basel, Switzerland)·2026
Same journal

Trueness and Precision of Intraoral Scanners for 3D-Printed Orthodontic Models with Attachments: An In Vitro Comparative Study.

Bioengineering (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K

Quantifying Information Exchange Between Cells in Inflammaging.

Israr B M Ibrahim1, Ramana M Pidaparti2

  • 1Department of Mechanical and Industrial Engineering, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

Bioengineering (Basel, Switzerland)
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Aging-related inflammation (inflammaging) impairs wound healing by altering cell communication. This study reveals inflammaging reduces cell information exchange, shifting network control from fibroblasts to macrophages, unlike normal inflammation.

Keywords:
agent-based modelinflammationnetwork topologytransfer entropy

More Related Videos

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

4.1K

Related Experiment Videos

Last Updated: Feb 28, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

4.1K

Area of Science:

  • Cellular Biology
  • Computational Biology
  • Immunology

Background:

  • Inflammaging, a chronic low-grade inflammation associated with aging, is linked to impaired wound healing.
  • Altered cell-cell communication is a hallmark of inflammaging, affecting tissue repair processes.

Purpose of the Study:

  • To investigate the dynamics of information exchange between macrophages and fibroblasts during normal inflammation and inflammaging.
  • To model and analyze network representations of cell-cell interactions in silico.

Main Methods:

  • Utilized an agent-based model to simulate cell migration and information exchange dynamics.
  • Constructed network representations to analyze cell-cell communication patterns.
  • Compared network topologies under conditions of normal inflammation with recovery versus inflammaging with sustained injury.

Main Results:

  • Inflammaging significantly reduces cell-cell information exchange and increases cellular dynamic noise compared to normal inflammation.
  • Normal inflammation exhibits higher network centrality in fibroblast nodes.
  • Inflammaging shifts network centrality towards macrophage nodes, indicating a change in primary interacting agents.

Conclusions:

  • Network topology analysis can characterize the course of inflammation and distinguish between normal and aging-related inflammatory processes.
  • Altered macrophage-fibroblast communication networks are a key feature of inflammaging, contributing to impaired healing.
  • Computational modeling provides insights into the complex cell-cell interactions governing inflammation and aging.