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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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Serial Intracranial Flow Rate Measurements Using Quantitative Magnetic Resonance Angiography Following Large-Vessel

Jean-Philippe Dufour1, Corinne Inauen2, Lara Höbner1

  • 1Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.

Brain Sciences
|February 27, 2026
PubMed
Summary

Quantitative MRA reveals that reduced arterial flow in large-vessel occlusion stroke patients is linked to worse outcomes, even after successful recanalization. This technique helps understand collateral pathways and flow dynamics post-stroke.

Keywords:
cerebrovascular circulationcerebrovascular disordershaemodynamicsischaemic strokemagnetic resonance angiographystrokethrombectomy

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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Area of Science:

  • Neurology
  • Medical Imaging
  • Cardiovascular Science

Background:

  • Hemodynamic changes post-ischemic large-vessel occlusion (LVO) stroke impact patient outcomes.
  • Endovascular recanalization aims to restore blood flow but may be influenced by residual hemodynamic alterations.
  • Quantitative MRA (qMRA) offers a non-invasive method to assess intracranial flow dynamics.

Purpose of the Study:

  • To investigate serial intracranial flow rate changes using qMRA in patients with LVO stroke.
  • To explore the development of collateral pathways and their relationship with flow rates.
  • To determine the clinical significance of these hemodynamic changes on patient outcomes.

Main Methods:

  • Prospective IMPreST study including patients with internal carotid artery or middle cerebral artery occlusions.
  • Early (<3 days) and late subacute (7 ± 3 days) qMRA flow measurements of M1-MCA, A2-ACA, and P2-PCA segments.
  • Analysis of flow rate ratios (ischemic/non-ischemic hemisphere) and correlation with clinical data (NIHSS, infarct size).

Main Results:

  • Recanalized patients showed symmetric M1 flow rate ratios, while non-recanalized patients had lower ratios.
  • Increased P2 flow rate ratios correlated negatively with M1 ratios, suggesting collateral activation.
  • Lower M1 flow rate ratios at 7 ± 3 days were associated with higher NIHSS at discharge in recanalized patients (p=0.02).
  • Total hemispheric flow decreased significantly between early and late measurements (p=0.005).

Conclusions:

  • qMRA is valuable for assessing flow status and collateral pathway activation in LVO stroke.
  • Reduced arterial flow in the subacute phase correlates with poorer neurological status, irrespective of recanalization success.
  • Understanding these hemodynamic changes can inform stroke management and outcome prediction.