Machine Learning Modeling for Codonopsis Radix Quality Assessment Integrating Efficacy, Chemical Composition, and...

This study aimed to develop an intelligent quality assessment system for Codonopsis Radix based on machine learning modeling. First, Codonopsis Radix samples from six origins were grouped based on pharmacological and chemical indicators, integrating pharmacodynamic evaluations using impaired spleen and lung function animal models with compositional analysis of the alcohol-soluble extract and polysaccharide contents. Subsequently, an electronic nose was employed to objectively quantify their odor profiles. A machine learning-based modeling framework was constructed by integrating feature extraction, feature selection, and pattern recognition techniques. The classification model built by combining electronic nose data with machine learning algorithms demonstrated highly effective discriminatory capability in cross-validation. SHapley Additive exPlanations analysis identified sensors S8, S15, S16, and S18 as critical variables for classification. Concurrently, regression models were established to predict the alcohol-soluble extract and polysaccharide contents. Given the limited sample size, feature expansion and data augmentation strategies were applied exclusively to the training set to enhance model robustness. In summary, the proposed interpretable modeling approach, which integrates pharmacological efficacy, chemical composition, and electronic nose data, provides a referential technical pathway for similar studies.