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Related Experiment Video

Updated: Feb 28, 2026

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

Bioartificial Cardiac Patches Functionalized with Apelin-13 Increase Cardiac C-Type Natriuretic Peptide Expression in

Manuela Cabiati¹, Claudia Kusmic¹, Letizia Guiducci¹

¹National Research Council (CNR), Institute of Clinical Physiology, Via G. Moruzzi 1, 56124 Pisa, Italy.

|February 27, 2026

Summary

This summary is machine-generated.

Apelin-13 functionalized patches (A-13p) modulate the C-type natriuretic peptide (CNP) system in myocardial infarction (MI) models. This suggests CNP is a therapeutic target for MI, promoting vascular remodeling and angiogenesis.

Keywords:

Apelin-13 C-type natriuretic peptide (CNP)Natriuretic peptides receptors VEGF functionalized patches

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Area of Science:

Cardiovascular Research
Regenerative Medicine
Molecular Biology

Background:

Regenerative medicine offers new approaches for repairing tissues after acute myocardial infarction (MI).
The C-type natriuretic peptide (CNP) system's role in MI and its modulation by Apelin-13 functionalized patches (A-13p) require further investigation.

Purpose of the Study:

To explore the involvement of the CNP system in myocardial infarction (MI).
To investigate the modulatory effects of Apelin-13 functionalized patches (A-13p) on the CNP system in an MI model.

Main Methods:

An experimental rat model of ischemia/reperfusion was used, with groups including Sham, Infarct, Sham with A-13p, and Infarct with A-13p.
Real-Time PCR was employed to analyze mRNA expression of CNP and its receptors (NPR-B, NPR-C) in cardiac tissue zones (infarct, border, remote).
Histological analysis assessed the impact of A-13p implantation.

Main Results:

A-13p implantation showed no adverse effects and reduced left ventricle wall thinning in the Infarct group.
CNP mRNA expression was elevated in infarcted zones compared to Sham.
NPR-B receptor expression was higher in the remote zone, while NPR-C was lower, with or without A-13p treatment.

Conclusions:

The CNP system plays a role in myocardial infarction (MI).
Apelin-13 functionalized patches (A-13p) modulate CNP expression in MI.
CNP emerges as a potential therapeutic target for regulating vascular remodeling and angiogenesis in MI treatment.