Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Multifaceted Role of Extracellular Vesicles in Triple Negative Breast Cancer.

International journal of molecular sciences·2026

Same author

Enhancing Healthcare Services for Vulnerable Aging Populations: A Comparative Analysis of Puerto Rico and International Case Studies.

Healthcare (Basel, Switzerland)·2026

Same author

Charting the virosphere: computational synergies of AI and bioinformatics in viral discovery and evolution.

Journal of virology·2025

Same author

Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype.

CNS oncology·2025

Same author

Implications of Krüppel-like factor signaling in neuroinflammation for neurodegenerative diseases.

American journal of translational research·2025

Same author

Immune evasion and resistance in breast cancer.

American journal of cancer research·2025

Search research articles

Related Experiment Video

Updated: Feb 28, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

Extracellular Vesicles in Tauopathies: Mechanisms and Applications.

Varun Nannuri¹, Ebaa Ababneh¹, Serena El Rayes¹

¹Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.

International Journal of Molecular Sciences

|February 27, 2026

Summary

Extracellular vesicles (EVs) are crucial in spreading tau pathology in neurodegenerative diseases. These EVs also hold potential as diagnostic biomarkers and therapeutic delivery vehicles for tauopathies.

Keywords:

biomarkers diagnosis extracellular vesicles tauopathy therapy

More Related Videos

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Published on: November 8, 2024

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Published on: May 23, 2021

Related Experiment Videos

Last Updated: Feb 28, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Published on: November 8, 2024

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Published on: May 23, 2021

Area of Science:

Neuroscience
Cell Biology
Biochemistry

Background:

Extracellular vesicles (EVs) are key mediators of intercellular communication.
EVs play significant roles in both normal physiological functions and pathological processes.
Tauopathies, characterized by tau protein accumulation, involve EVs in disease propagation and progression.

Purpose of the Study:

To review the multifaceted roles of EVs in tauopathies.
To highlight EVs' involvement in tau pathology transmission, immune modulation, and biomarker potential.
To assess the therapeutic applications and challenges associated with EVs in tauopathies.

Main Methods:

Literature review of recent studies on EVs and tauopathies.
Analysis of EV cargo, including tau, miRNAs, and mRNAs.
Evaluation of therapeutic strategies utilizing EVs.

Main Results:

EVs actively transport and spread misfolded tau aggregates.
EVs interact with microglia, modulating immune responses in the brain.
EV-derived molecules (tau, miRNAs, mRNAs) show promise as diagnostic biomarkers for Alzheimer's disease and related tauopathies.
EVs can be engineered for targeted delivery of therapeutics.

Conclusions:

EVs are central to tauopathy pathophysiology, serving as diagnostic indicators and therapeutic platforms.
Standardization of EV isolation, cargo loading, and biodistribution are critical for clinical translation.
EVs represent a promising avenue for precision medicine in treating neurodegenerative diseases.