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Related Experiment Video

Updated: Feb 28, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Effects of Physical Exercise on Circulating Serotonin Levels: A Systematic Review and Meta-Analysis.

Aarón Barrero-Osorio1, Juan Manuel Franco-García1, Damián Pereira-Payo1

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Healthcare (Basel, Switzerland)
|February 27, 2026
PubMed
Summary

Physical exercise (PE) does not significantly alter serotonin levels in women, according to this review. More high-quality studies are needed to confirm the impact of exercise on this mood-regulating neurotransmitter.

Keywords:
5-Hydroxytryptaminemodulationphysical activitytraining

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Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Biochemistry

Background:

  • Serotonin is a key neurotransmitter regulating mood and human health.
  • Physical exercise (PE) is explored as a non-pharmacological method to influence serotonin levels.

Purpose of the Study:

  • To systematically review and meta-analyze the effects of physical exercise on circulating serotonin concentrations.
  • To assess the current evidence regarding exercise's impact on serotonin.

Main Methods:

  • Systematic review and meta-analysis following PRISMA guidelines.
  • Included 5 randomized controlled trials (RCTs) with 116 female participants.
  • Used random-effects meta-analysis and sensitivity analyses; assessed study quality via PEDro scale.

Main Results:

  • Pooled analysis revealed a non-significant effect of PE on serotonin levels (SMD 1.48, p=0.135).
  • Extremely high heterogeneity (I²=94.63%) was observed across studies.
  • Sensitivity analyses confirmed non-significant results and high heterogeneity.

Conclusions:

  • Current evidence, solely from female participants, does not support a significant effect of PE on serotonin levels.
  • High heterogeneity and moderate study quality limit current conclusions.
  • Further high-quality RCTs with standardized protocols are necessary to clarify exercise's influence on serotonin.