Related Experiment Video
Updated: Feb 28, 2026
04:16
Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
947
Associations Between Gut Microbiome Enterotypes and Body Weight Change During Whole Milk Consumption
Panpan Qin1, Lelde Berzina1, Nina Rica Wium Geiker2,3
1Laboratory of Integrative Biomedicine, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
Nutrients
|February 27, 2026
Summary
Gut microbiome enterotypes influence weight loss. The Bacteroides1 enterotype showed decreased body weight after whole milk consumption, unlike the Ruminococcaceae enterotype, highlighting personalized nutrition potential.
Area of Science:
- Microbiome research
- Nutritional science
- Metabolic health
Background:
- Gut bacteria influence dietary intervention outcomes.
- Enterotypes may predict individual responses to diet.
- Obesity management requires personalized approaches.
Purpose of the Study:
- Correlate gut microbial enterotypes with obesity outcomes.
- Investigate effects of whole milk consumption on body weight and metabolites.
- Analyze enterotype-specific responses to dietary changes.
Main Methods:
- Post hoc analysis of a one-month whole milk consumption trial.
- Shotgun metagenomic sequencing for gut microbiome analysis.
- Comparison of body weight, urinary, and fecal metabolites between Bacteroides1 (B1) and Ruminococcaceae (R) enterotypes.
Main Results:
- Bacteroides1 enterotype individuals showed decreased body weight and Streptococcus thermophilus abundance.
- Enterotype was a significant predictor of body weight change (p=0.0034).
- Urinary taurine changes correlated with body weight changes in B1 individuals only.
Conclusions:
- Dietary interventions elicit enterotype-specific responses.
- Enterotype data can refine nutrition intervention design.
- Personalized nutrition strategies can leverage enterotype information.
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