Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K
COP Coated Vesicles00:59

COP Coated Vesicles

18.4K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
18.4K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.3K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

5.0K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.0K
Exocytosis00:51

Exocytosis

74.1K
Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
74.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sphingolipid Expression During Corneal Wound Healing in a Sphingosine Kinase 1 Knockout Model.

Cells·2026
Same author

Extracellular Vesicles in Ophthalmology: From Natural Nanocarriers to Engineered Therapeutics.

Bioengineering (Basel, Switzerland)·2026
Same author

Whole-blood transcriptomic analysis reveals preoperative complement inhibitor deficiencies linked to postoperative delirium.

Molecular psychiatry·2025
Same author

Fabrication of a 3D Corneal Model Using Collagen Bioink and Human Corneal Stromal Cells.

Journal of functional biomaterials·2025
Same author

Decreased Circulating Gonadotropin-Releasing Hormone Associated with Keratoconus.

Cells·2024
Same author

Amelioration of Fibrosis via S1P Inhibition Is Regulated by Inactivation of TGF-β and SPL Pathways in the Human Cornea.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Feb 28, 2026

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
09:36

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

4.5K

Corneal Extracellular Vesicles: Small Packages with a Big Impact.

Brenna S Hefley1,2, Pawan Shrestha1,2, Tina B McKay3

  • 1North Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.

Pharmaceutics
|February 27, 2026
PubMed
Summary

Extracellular vesicles (EVs) are key to cell communication and show promise for treating corneal diseases. Further research into EVs will improve diagnostics and therapies for eye conditions.

Keywords:
biological fluidcharacterizationexosomeextracellular vesiclestherapeutics

More Related Videos

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

940
Setting a Successful Sorting for Extracellular Vesicle Isolation
08:37

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 28, 2026

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
09:36

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

4.5K
Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

940
Setting a Successful Sorting for Extracellular Vesicle Isolation
08:37

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

1.7K

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biotechnology

Background:

  • Extracellular vesicles (EVs) are crucial mediators of intercellular communication.
  • EVs facilitate the transfer of molecular cargo between cells.
  • Their role in corneal diseases is an emerging area of research.

Purpose of the Study:

  • To review the biology of EVs in corneal diseases.
  • To discuss current therapeutic applications of EVs.
  • To highlight the potential of EVs as biomarkers and drug delivery vehicles.

Main Methods:

  • Literature review of studies on EVs and corneal diseases.
  • Analysis of EV surface markers for tissue specificity.
  • Discussion of technological advancements in EV research.

Main Results:

  • EVs possess tissue-specific surface markers, beneficial for targeted drug delivery.
  • EVs show potential as biomarkers for studying disease progression.
  • Current therapeutic strategies utilizing EVs are under development.

Conclusions:

  • EVs hold significant promise for diagnosing and treating corneal diseases.
  • Advances in technology are crucial for realizing the full potential of EVs.
  • Future research should focus on overcoming current limitations and identifying new therapeutic targets.