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Updated: Feb 28, 2026

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Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides

Xiao-Qi Liu1,2, Ru Li1,2, Jun-Liang Chen1,2

  • 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

JACS Au
|February 27, 2026
PubMed
Summary

Researchers reprogrammed imine reductases (IREDs) to enantioselectively reduce enamides, creating chiral amines. This breakthrough expands biocatalyst capabilities for synthesizing valuable amine compounds.

Keywords:
chiral amidedirected evolutionenamide reductionimine reductase

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