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Detection of monkeypox skin lesions using edge enhancement algorithms integrated with hybrid deep learning
Hoor Ul Ain1, Shabana Ramzan1, Muhammad Munwar Iqbal2
1Department of Computer Science and IT, Government Sadiq College Women University, Bahawalpur, Pakistan.
Digital Health
|February 27, 2026
Summary
A new deep learning framework offers improved monkeypox lesion detection from skin images. This AI approach enhances diagnostic accuracy and reduces risks for healthcare workers, aiding global health responses.
Area of Science:
- Artificial Intelligence in Dermatology
- Medical Image Analysis
- Infectious Disease Diagnostics
Background:
- Monkeypox poses a global health threat, necessitating advanced detection methods beyond traditional polymerase chain reaction (PCR).
- PCR is limited by cost, time, and contagion risks to healthcare professionals.
- Innovative solutions are crucial for efficient and safe monkeypox diagnosis.
Purpose of the Study:
- To introduce a lightweight deep learning framework for enhanced monkeypox lesion detection using skin images.
- To improve the accuracy and efficiency of monkeypox diagnosis through AI.
Main Methods:
- A novel edge enhancement algorithm incorporating contrast-limited adaptive histogram equalization and bilateral filters was applied to refine skin images.
- The framework was evaluated using six pre-trained deep learning models and a hybrid model (DenseNet121 + ConvNeXt-Tiny, DN-CXT).
- Performance metrics included accuracy, F1-score, and precision, with optimization via Adam, RMSprop, and SGD.
Main Results:
- The proposed DN-CXT model demonstrated superior performance with 97% test accuracy, 97% F1-score, and 99% precision.
- Other models like DenseNet121, MobileNetV2, InceptionV3, and ConvNeXt-Tiny also yielded high performance.
- The framework effectively enhances monkeypox lesion detection from skin images.
Conclusions:
- The developed deep learning framework significantly advances medical image analysis for monkeypox lesion detection.
- AI-driven methodologies can be integrated into monkeypox detection workflows for improved diagnostic efficiency.
- This approach enhances healthcare response to emerging infectious diseases and reduces risks to medical personnel.

