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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Related Experiment Video

Updated: Feb 28, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.

Sara El Aouhel1, Vanessa Bellegarde2, Stennio Da Silva Faria1

  • 1CHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.

American Journal of Hematology
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Genetic propensity for asthma increases frequent acute chest syndrome (ACS) in sickle cell disease (SCD) patients with low fetal hemoglobin (HbF). Combining asthma polygenic scores (PGSasthma) and HbF identifies high-risk individuals for personalized management.

Keywords:
acute chest syndromeasthmapolygenic scorerisk stratificationsickle cell disease

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Area of Science:

  • Genetics
  • Hematology
  • Pulmonology

Background:

  • Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD), impacting approximately 50% of patients.
  • Current tools are insufficient for identifying individuals at high risk of ACS occurrence or frequent episodes.
  • Epidemiological studies suggest an association between asthma and ACS, but a causal link remains unclear.

Purpose of the Study:

  • To investigate whether a genetic predisposition for asthma is associated with ACS in SCD patients.
  • To determine if polygenic scores for asthma (PGSasthma) can stratify ACS risk.
  • To explore the combined effect of PGSasthma and fetal hemoglobin (HbF) on frequent ACS episodes.

Main Methods:

  • Utilized polygenic scores (PGS) to assess the genetic propensity for asthma in relation to ACS.
  • Analyzed data from two prospective SCD cohorts: CSSCD (n=1278) and GEN-MOD (n=406).
  • Examined the association of PGSasthma with ACS rate and occurrence, independent of HbF levels, and assessed genetic correlation.

Main Results:

  • PGSasthma was significantly associated with the rate of ACS episodes (p=0.006) but not ACS occurrence in both cohorts.
  • This association was more pronounced in patients with lower HbF levels.
  • Combining high PGSasthma and low HbF identified a subgroup at high risk for frequent ACS after a first episode.

Conclusions:

  • A high genetic propensity for asthma is linked to frequent ACS in SCD patients, particularly when HbF levels are low.
  • The combination of PGSasthma and HbF levels can identify patients at high risk for frequent ACS.
  • These findings suggest potential for personalized management strategies in SCD patients prone to ACS.