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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
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Should Sickle Cell Disease Be Considered a Cancer Predisposition Syndrome?

Elise Casadessus1,2, Yves Pastore1,2,3, Thomas Pincez1,2,3

  • 1Division of Pediatric Hematology-Oncology, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.

Children (Basel, Switzerland)
|May 27, 2026
PubMed
Summary

Sickle cell disease (SCD) patients have a higher risk of leukemia, particularly acute myeloid leukemia (AML). While sharing some traits with cancer predisposition syndromes, SCD

Keywords:
acute myeloid leukemiacancer predisposition syndromesclonal hematopoiesisleukemogenesissickle cell disease

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Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Sickle cell disease (SCD) is associated with various complications, including a potential increased risk of certain cancers.
  • Previous studies suggest a higher incidence of leukemia, especially acute myeloid leukemia (AML), in individuals with SCD.
  • The relationship between SCD and solid tumors remains less clear, but leukemia risk appears to emerge in childhood and persist lifelong.

Purpose of the Study:

  • To investigate whether sickle cell disease (SCD) should be classified as a cancer predisposition syndrome.
  • To compare the characteristics of SCD-associated acute myeloid leukemia (AML) with those of known cancer predisposition syndromes.
  • To explore the underlying mechanisms contributing to leukemogenesis in SCD.

Main Methods:

  • Comparative analysis of SCD-associated AML features against established cancer predisposition syndromes.
  • Review of molecular specificities of SCD-associated AML.
  • Examination of shared pathogenetic mechanisms, including ineffective erythropoiesis, chronic inflammation, and oxidative stress.

Main Results:

  • SCD-associated AML shares some characteristics with cancer predisposition syndromes, including a restricted malignancy type and molecular similarities to therapy-related AML.
  • Mechanisms like ineffective erythropoiesis, increased cell renewal, chronic inflammation, and oxidative stress are implicated in both SCD-associated leukemogenesis and cancer predisposition syndromes.
  • However, the relative cancer risk in SCD is significantly lower than in most cancer predisposition syndromes, and the absolute risk of malignancy in SCD patients is low.

Conclusions:

  • Sickle cell disease (SCD) exhibits unique features distinct from typical cancer predisposition syndromes, particularly regarding the magnitude of cancer risk.
  • While SCD shares some pathophysiological pathways with cancer predisposition syndromes, its overall cancer risk profile is considerably lower.
  • Clinicians should be aware of the elevated AML risk in SCD patients for appropriate management and counseling, despite the low absolute risk.