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Updated: Feb 28, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
The Electrochemical Functionalization of N-H Bond on N-Heterocycles with Isocyanides to Synthesize Azole Urea
Tan Zhang1, Wenhui Wang1, Mingqi Chen1
1School of Chemistry and Materials Science, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
Abstract:
A selective protocol for the synthesis of azole ureas and diheterocycle substituted methanimines from nitrogenous heterocycles and isocyanides was established under electrochemical reaction conditions. By adjustment of the reaction conditions such as electrode materials and solvents, two different types of heterocyclic derivatives of significant value could be selectively obtained with high yields. The reactions have several advantages such as simple reaction conditions and high chemoselectivity and are suitable for various nitrogenous heterocycles and isocyanides.
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