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Updated: Feb 28, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
Efficacy of low-concentration nitrous oxide gas anesthesia in routine cataract microsurgeries
Kaori Morii1, Kotaro Ishigami2, Shinji Miura2
1Morii Eye Clinic, Ueda Bild.2F,1-6-9 Mikagenakamachi, Higashi Nada, Kobe City, 658-0054, Hyogo Prefecture, Japan. k-morii@morii-eye.com.
Key Messages:
WHAT IS KNOWN : • Low-concentration nitrous oxide (LCNO) has been used in dentistry and some ophthalmic procedures and is believed to reduce anxiety and discomfort. • Evidence for its sedative effect in cataract microsurgery has largely relied on subjective patient reports rather than objective monitoring.
What Is New:
• This study provides objective evidence, using bispectral index (BIS) monitoring, that LCNO induces mild sedation during routine cataract microsurgery. • LCNO significantly reduced the BIS values during surgery without causing clinically relevant changes in the vital signs or adverse events, supporting its safety and practicality for outpatient cataract surgery.
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