Interrelationship between lipid and bone metabolism in postmenopausal women

Aim: To study the state and interrelationship of calcium-phosphorus metabolism, lipid profile, and bone mineral density in postmenopausal women.

Materials and Methods: A retrospective cohort study was conducted involving 42 women aged 51.9±2.95 years, with a postmenopausal period of 1.69±1.47 years. All patients underwent laboratory and instrumental examinations.

Results: The study found that most women were overweight or obese and had elevated levels of total cholesterol, low-density lipoprotein cholesterol, and atherogenicity index. The average level of 25(OH)D was 26.95±10.58 ng/ml, with more than half of the subjects diagnosed with deficiency or insufficiency. According to ultrasound densitometry, a significant proportion of women had varying degrees of BMD reduction, ranging from osteopenia to osteoporosis. Correlation analysis revealed statistically significant associations between lipid profile indicators, calcium-phosphorus metabolism, and bone tissue condition, in particular inverse correlations between HDL-C levels and phosphorus, parathyroid hormone, and alkaline phosphatase, as well as between the atherogenicity coefficient and vitamin D levels (p<0.05).

Conclusions: The data obtained confirm the feasibility of a comprehensive assessment of calcium-phosphorus metabolism, lipid profile, and ultrasound densitometry results. This approach allows for the timely identification of women at increased risk of developing osteodismetabolic disorders and monitoring of bone tissue condition in the postmenopausal period.