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Exploring the Contribution of Interleukin-17 Genetic Polymorphisms to Pterygium Risk.

Hung-Chih Chen1,2, Ning-Yi Hsia3, Pei-Shin Hu1,3

  • 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

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|February 27, 2026
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Summary

The IL17A rs2275913 gene variant is linked to a higher risk of developing pterygium, an eye condition. This genetic association is particularly strong in older females within the Taiwanese population.

Keywords:
GenotypeIL17A rs2275913disease susceptibilitygenetic polymorphisminterleukin-17pterygium

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Area of Science:

  • Ophthalmology
  • Genetics
  • Immunology

Background:

  • Pterygium is a chronic ocular disorder with tumor-like characteristics.
  • Interleukin-17 (IL17) is implicated in pterygium pathogenesis, but its genetic contribution is unclear.

Purpose of the Study:

  • Investigate the association between IL17A rs2275913 and IL17F rs763780 polymorphisms and pterygium susceptibility in Taiwanese individuals.
  • Determine if IL17A genotype interacts with age or sex.

Main Methods:

  • Case-control study involving 160 pterygium patients and 320 controls.
  • Genotyping performed using polymerase chain reaction-restriction fragment length polymorphism.
  • Stratified analysis used to test for interactions between IL17A genotype, age, and sex.

Main Results:

  • The IL17A rs2275913 A allele and AA genotype were significantly associated with increased pterygium risk (OR=1.42 and OR=1.92, respectively).
  • No significant association was found for IL17F rs763780.
  • Stronger effects of IL17A rs2275913 were observed in individuals aged 60 years or older and in females.

Conclusions:

  • The IL17A rs2275913 polymorphism is a significant risk factor for pterygium in the Taiwanese population.
  • This finding suggests a genetic basis for IL17-mediated inflammation in pterygium.
  • IL17A rs2275913 may serve as a potential biomarker for pterygium susceptibility.