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Dengue nanosensors: a roadmap for clinical viability
Helena Codina1, Marta Quero-Delgado1, Rafael Gómez2
1Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Dengue nanosensors show promise but lack clinical success due to prioritizing sensitivity over robustness. A new roadmap focuses on product engineering for reliable dengue diagnostics, moving from lab to patient care.
Area of Science:
- Biomedical Engineering
- Diagnostic Technologies
- Nanotechnology
Background:
- Nanosensors offer potential for dengue diagnosis.
- Clinical application of dengue nanosensors has been limited.
- Existing approaches often prioritize sensitivity over practical robustness.
Purpose of the Study:
- To address the gap between dengue nanosensor potential and clinical reality.
- To propose a new paradigm focusing on product engineering for diagnostic development.
- To provide a translational roadmap for viable dengue diagnostics.
Main Methods:
- Shift focus from materials discovery to product engineering principles.
- Develop a roadmap for translating nanosensor technology from laboratory to clinical settings.
- Emphasize real-world robustness alongside sensitivity.
Main Results:
- Identified the paradox of high sensitivity but low clinical utility in dengue nanosensors.
- Proposed a strategic shift towards engineering robust diagnostic products.
- Outlined a translational pathway for effective dengue diagnostic tools.
Conclusions:
- Overcoming the limitations of current dengue nanosensors requires a focus on product engineering.
- A translational roadmap is essential for bringing robust dengue diagnostics to patients.
- The proposed paradigm shift can facilitate successful clinical application of nanosensor technology.
