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Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
[Y-chromosome haplogroups and risk of cardiovascular diseases (literature review)]
A V Chechulova1, V V Soroka1, A V Gorbunova2
1St. Petersburg Research Institute of Emergency Medicine named after I.I. Dzhanelidze, 192242, Saint Petersburg, Russian Federation.
Insights
The Y-chromosome may play a role in regulating cardiovascular function, potentially serving as a genetic marker for polygenic cardiovascular diseases. Research explores its association with Y-DNA haplogroups.
Area of Science:
- Genetics
- Cardiology
- Human Evolution
Abstract:
This article is a review of the most relevant information concerning the nature of polygenic diseases, considering the mechanisms of pathogenesis of cardiovascular diseases from the point of view of their regulation by genes located on the Y-chromosome, with a detailed analysis of the literature data dedicated to studying the association of polygenic diseases with the Y-chromosome and Y-DNA haplogroups. Various countries over the past decades, based on which a conclusion was drawn on-possible involvement of the Y-chromosome in regulation of the function of the cardiovascular system, which may serve as one of the strongest genetic markers of cardiovascular diseases.
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