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Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation

Yibo Zuo1, Qin Wang2, Wanying Tian3

  • 1Department of Laboratory Medicine, Institute of Laboratory Medicine, Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan-Chongqing Joint Key Laboratory for Pathology and Laboratory Medicine and Jinfeng Laboratory, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China; The First Affiliated Hospital of Soochow University, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou 215123, Jiangsu, China.

Cell
|February 28, 2026
PubMed

Keywords:
STAT1antiviral immunityinnate immunityinterferonpyruvatepyruvylation

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