Related Experiment Video
Updated: Mar 2, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Clinical Characteristics and Outcomes in Central Serous Chorioretinopathy With Subretinal Hyper-Reflective Material:
Niroj Kumar Sahoo1, Nasiq Hasan2, Ninan Jacob1
1From the Anant Bajaj Retina Institute (N.K.S., N.J.), Kode Venkatadri Chowdary Campus, LV Prasad Eye Institute, Vijayawada, Andhra Pradesh, India.
Purpose:
To evaluate the clinical features and longitudinal outcomes of chronic central serous chorioretinopathy (CSCR) presenting with subretinal hyperreflective material (SHRM).
Design:
Retrospective, multicenter clinical cohort study from the Macula Society CSCR Study Group.
Participants:
This study included consecutive patients with a diagnosis of CSCR, with and without SHRM.
Methods:
Baseline and final best-recorded visual acuity (BRVA) and multimodal imaging parameters were compared between SHRM and non-SHRM groups.
Main Outcome Measures:
Longitudinal changes in BRVA and imaging parameters in both groups; factors affecting subretinal fluid (SRF) persistence, and change in BRVA.
Results:
A total of 503 eyes (103 with SHRM and 400 eyes without SHRM) were analyzed. The SHRM group showed poorer baseline BRVA (0.4 ± 0.3 logMAR; 20/50) compared to the non-SHRM group (0.2 ± 0.3 logMAR; 20/30) (p = .006). SHRM eyes demonstrated greater RPE alteration (p = .04), higher neurosensory retinal detachment (p < .001), more photoreceptor irregularities (p = .004), hyperreflective foci (p < .001), and double-layer sign (p < .001). The incidence of concurrent macular neovascularization (p = .01) and persistent subretinal fluid (p < .001) was higher in the SHRM group. Despite visual improvement in both groups, final height of neuro-sensory detachment (p < .001) remained higher in SHRM eyes. Eyes with a history of steroid exposure and ellipsoid zone (EZ) loss (post-resolution) were greater in higher SHRM grades. Logistic regression revealed non-SHRM status, and combination therapy had lower odds of SRF persistence.
Conclusion:
CSCR with SHRM presented with worse initial vision. Although vision improved after treatment, persistent SRF and EZ loss (in resolved cases) remain more frequent in SHRM eyes.
