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Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Related Experiment Video

Updated: Mar 2, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Exploring Cellular and Molecular Mechanisms Involved in UV-induced Skin Photo-aging.

Neeraj Bainsal1, Chandan Sharma1, Arpan Kumar Tripathi2

  • 1University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India.

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Summary

Natural compounds like polyphenols and flavonoids combat UV-induced skin aging by reducing wrinkles and improving hydration. Further research is needed to confirm long-term effectiveness and safety of these natural compounds.

Keywords:
SkinUV radiationcellular and molecular mechanisms.natural productsphotoagingphytoconstituents

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Photobiology

Background:

  • Skin aging is accelerated by ultraviolet (UV) radiation exposure, particularly in sun-exposed areas.
  • UV radiation induces cellular and molecular damage, leading to visible signs of photoaging such as wrinkles and pigmentation.
  • Naturally derived compounds are being investigated for their potential to mitigate UV-induced skin damage.

Purpose of the Study:

  • To investigate the mechanisms by which UV light causes skin photoaging.
  • To evaluate the efficacy of natural compounds in counteracting UV-induced skin aging.
  • To identify specific natural compounds and their effects on key skin aging parameters.

Main Methods:

  • Systematic literature review of preclinical and clinical studies from Web of Science and PubMed.
  • Analysis focused on measurable outcomes: wrinkle depth, pigmentation, skin hydration, and collagen content.
  • Evaluation of proposed mechanisms of action for natural compounds.

Main Results:

  • Certain polyphenols, flavonoids, and carotenoids demonstrated significant improvements in skin health.
  • Reductions in wrinkle depth (up to 23%), increased hydration (15-20%), and boosted collagen density (12-18%) were observed within 8-12 weeks.
  • Mechanisms include inhibition of matrix metalloproteinases, reactive oxygen species neutralization, and TGF-β signaling activation.

Conclusions:

  • Naturally derived compounds show considerable promise in protecting skin against UV-induced aging.
  • Further rigorous clinical trials are essential to optimize formulation, bioavailability, and long-term efficacy and safety.
  • These natural compounds offer a potential avenue for developing effective anti-photoaging strategies.