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Inavolisib-based Combination Therapy for the Treatment of PIK3CAMutated HR+/HER2- Breast Cancer: An Overview

Sushmita Bhatia1, Neha Bhatia1, Suresh Thareja1

  • 1Department of Pharmaceutical Sciences and Natural Products, School of Pharmaceutical Sciences, Central University of Punjab, Bathinda, Punjab 151401, India.

Mini Reviews in Medicinal Chemistry
|March 1, 2026
PubMed
Summary

Inavolisib, a PI3Kα inhibitor, shows promise for PIK3CA-mutated breast cancer. This next-generation drug offers improved efficacy and tolerance, targeting key cancer pathways.

Keywords:
InavolisibPI3Kα inhibitorendocrine resistancefulvestrantpalbociclibpharmacokineticstargeted therapy

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