Real-world treatment sequences and overall survival in metastatic bladder cancer: The STATES-Bladder study

The treatment landscape for metastatic urothelial carcinoma (mUC) has rapidly evolved with immune checkpoint inhibitors (ICI), FGFR-targeted therapies, antibody-drug conjugates, and more recently first-line enfortumab vedotin (EV) plus pembrolizumab. In many countries, this combination is not yet available, and the standard of care (SOC) remains platinum-based chemotherapy (PBC) followed by ICI. Real-world data on treatment sequencing and attrition across therapy lines in unselected populations are limited.

We analyzed patients with mUC treated between January 2020 and December 2023 across 4 French oncology centers. Eligible patients had received at least 1 cycle of PBC. Overall survival (OS), treatment sequences, and attrition rates were assessed. Survival was estimated using Kaplan-Meier methods.

A total of 180 patients were included (median age 72 years; 81% male; 84% urothelial carcinoma). All received first-line PBC; 127 (71%) were non-progressive and eligible for avelumab maintenance, but 24 (19%) did not receive it. Only 54 patients (64%) received second-line therapy, and 45 (25%) reached third-line treatment. Median OS was 22.4 months (95% CI: 17.2-26.7). Patients receiving PBC followed by avelumab maintenance achieved a median OS of 29.0 months, compared with 15.6 months for not reponsders PBC patients. Patients with ECOG 2 to 3 (n = 36) had poor outcomes (median OS 7.2 months vs. 26.4 months for ECOG 0-1; P < 0.001).

This study confirms the real-world effectiveness of contemporary treatment sequences, highlights significant attrition between therapy lines, and underscores the need for upfront use of effective agents, particularly in patients with poor performans status.