Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

8.4K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

549
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
549
Cancer Survival Analysis01:21

Cancer Survival Analysis

805
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
805
Cause and Effect01:53

Cause and Effect

12.6K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
12.6K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

2.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of Lung Cancer Risk Prediction Models in Different Racial and Ethnic Groups in the United States: Results From the Lung Cancer Cohort Consortium.

Annals of internal medicine·2026
Same author

Adherence to the Mediterranean diet and risk of pancreatic cancer: an analysis of 2.3 million participants in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP).

European journal of epidemiology·2026
Same author

Effects of breast cancer risk factors on the tumor microenvironment: a morphological deep-learning analysis of three prospective cohorts.

NPJ breast cancer·2026
Same author

Healthcare contact days in cancer survivors relative to those with no cancer history.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer.

JAMA network open·2026
Same author

Co-occurring health behaviors and mental health outcomes among a large, aging US population.

Frontiers in public health·2026
Same journal

Diet and Cognitive Function in Aging: An Individual Participant Data Meta-Analysis from Eight Cohorts in Europe and the United States.

The Journal of nutrition·2026
Same journal

Food as Medicine in Los Angeles County: Policy and Practice Insights from a 2025 Convening.

The Journal of nutrition·2026
Same journal

Longitudinal associations of total and class-specific polyphenol intake with incident type 2 diabetes and changes in glycemic markers: Findings from the ELSA-Brasil cohort.

The Journal of nutrition·2026
Same journal

Food on the go: How engagement with the food environment affects adolescent diets in Northern Vietnam.

The Journal of nutrition·2026
Same journal

Cardiometabolic Risk in U.S. Pregnant Women and Associations with Food Insecurity, Diet Quality, and Special Supplemental Nutrition Program for Women, Infants, and Children Participation.

The Journal of nutrition·2026
Same journal

Maternal Body Mass Index Attenuates Response to High-Dose Vitamin D Supplementation During Pregnancy: A Secondary Analysis of the VDAART Randomized Trial.

The Journal of nutrition·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.8K

Association between Aspartame Consumption and Cancer Risk: Evidence from a Large Prospective Cohort.

Xinyu Zhu1, Jean A Welsh2, Marjorie L McCullough3

  • 1Nutrition and Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, United States.

The Journal of Nutrition
|March 1, 2026
PubMed
Summary
This summary is machine-generated.

Aspartame consumption is linked to increased cancer risk, including obesity-related and non-obesity-related cancers. Further research is needed due to the lack of a clear dose-response relationship.

Keywords:
artificially sweetened beveragesaspartamecancerlow-calorie sweetenerobesityprospective cohort study

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.3K

Related Experiment Videos

Last Updated: Mar 3, 2026

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.8K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.3K

Area of Science:

  • Oncology
  • Nutritional Epidemiology
  • Public Health

Background:

  • Aspartame, a common low-calorie sweetener, has been classified as possibly carcinogenic.
  • Inconsistent epidemiologic evidence necessitates further large prospective studies on aspartame and cancer risk.
  • Specific focus is needed on obesity-related cancers and aspartame consumption.

Purpose of the Study:

  • To investigate the association between aspartame intake and the risk of all cancers combined.
  • To examine aspartame intake in relation to obesity-related cancers (ObCa) and non-obesity-related cancers (non-ObCa).
  • To analyze aspartame's link with digestive and female reproductive ObCa subgroups.

Main Methods:

  • Utilized data from the Cancer Prevention Study-II (CPS-II) Nutrition Cohort (NC) of 100,004 adults.
  • Assessed aspartame intake from beverages and packets via food frequency questionnaires in 1999 and 2003.
  • Employed multivariable-adjusted Cox proportional hazards models to analyze cancer risk, adjusting for baseline weight status.

Main Results:

  • Aspartame consumers showed higher risks for all cancers combined, non-ObCa, ObCa, digestive ObCa, and female reproductive ObCa compared to non-consumers.
  • Adjusted hazard ratios indicated increased risk across various cancer types (e.g., aHR=1.13 for all cancers).
  • No clear dose-response relationship was observed, and associations were not modified by weight status.

Conclusions:

  • Aspartame consumption is associated with elevated cancer risk, encompassing both obesity-related and non-obesity-related cancers.
  • The findings suggest a potential link between aspartame and increased cancer incidence.
  • The absence of a dose-response relationship warrants cautious interpretation and further investigation.