[Interpretation of FUTURE-AI, the International Consensus Guideline for Trustworthy and Deployable Artificial...

Artificial intelligence (AI) has been widely used in healthcare research, such as disease prevention and diagnosis. However, only a limited number of AI tools have been adopted in health practice due to significant clinical, technical, socio-ethical, and legal challenges. The International Consensus Guideline for Trustworthy and Deployable AI in Healthcare (guideline) was established in 2025 to promote trustworthy and ethical AI in healthcare. The guideline was based on six guiding principles-fairness, universality, traceability, usability, robustness, and explainability (FUTURE-AI), and a set of 30 best clinical practices was defined for operationalization, covering the entire lifecycle of healthcare AI. In this study, we briefly introduced and interpreted the core principles and 30 best practices of the guideline. Our study provides a reference for the design, development, evaluation, and deployment of trustworthy AI tools in healthcare (particularly, epidemiological research) in China.