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Methods for Skin Wounding and Assays for Wound Responses in C. elegans
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Characterizing Laser-Induced Wound Healing Dynamics Using Line-Field Confocal Optical Coherence Tomography.

Gabriela Pinero-Crespo1, Thomas M Beachkofsky2

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Lasers in Surgery and Medicine
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Summary
This summary is machine-generated.

Line-field optical coherence tomography (LC-OCT) effectively visualized tissue healing after UltraClear Laser-Coring treatment. Serial imaging revealed distinct epidermal and dermal repair patterns, supporting LC-OCT

Keywords:
fractional laser resurfacingline‐field confocal optical coherence tomographywound healing

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • UltraClear Laser-Coring treatment creates microchannels in the skin.
  • Understanding the early tissue response is crucial for optimizing treatment outcomes.
  • Line-field optical coherence tomography (LC-OCT) offers high-resolution, non-invasive imaging capabilities.

Purpose of the Study:

  • To evaluate the utility of serial LC-OCT imaging in visualizing early tissue response patterns after UltraClear Laser-Coring.
  • To assess the impact of a regenerative serum on the healing process compared to a control.
  • To document the in vivo imaging characteristics of laser-created microchannels over time.

Main Methods:

  • A single subject underwent UltraClear Laser-Coring treatment on bilateral forearms.
  • One arm received a regenerative serum; the other received petroleum jelly as a control.
  • Serial LC-OCT imaging was performed from Day 1 to Day 18 to monitor microchannel healing.

Main Results:

  • LC-OCT visualized progressive epithelialization of microchannels, achieving near-complete surface continuity by Day 4.
  • Stratum corneum-like layers reformed, and cellular changes indicative of healing were observed.
  • Dermal remodeling, including vessel dilation and fiber definition, was noted between Days 8 and 18.
  • No significant differences in healing patterns were observed between the serum-treated and control sites.

Conclusions:

  • Serial LC-OCT imaging is effective for documenting in vivo tissue responses to UltraClear Laser-Coring.
  • Distinct epidermal and dermal healing patterns were identified using LC-OCT.
  • This study supports the feasibility of using LC-OCT for real-time visualization of laser-induced tissue effects.