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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Muscle Contraction01:15

Muscle Contraction

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Muscle Contraction01:10

Muscle Contraction

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In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive...
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Related Experiment Video

Updated: Mar 3, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease
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Tissue Triage and Freezing for Models of Skeletal Muscle Disease

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What Is in the Myopathy Literature?

Michael Isfort1, David Lacomis2

  • 1Department of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH; and.

Journal of Clinical Neuromuscular Disease
|March 2, 2026
PubMed
Summary

This review covers treatable myopathies, including those linked to medications like sertraline and statins, and genetic disorders such as muscular dystrophies and Pompe disease.

Keywords:
MRImuscular dystrophymyopathymyositisstatinsultrasound

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Related Experiment Videos

Last Updated: Mar 3, 2026

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Area of Science:

  • Neurology
  • Muscle Diseases
  • Pharmacology

Background:

  • Myopathies encompass a range of muscle disorders with diverse etiologies.
  • Understanding the specific causes and presentations is crucial for effective management.
  • Recent research has shed light on drug-induced, genetic, and autoimmune myopathies.

Purpose of the Study:

  • To provide a comprehensive overview of recent advancements in the understanding and treatment of various myopathies.
  • To highlight treatable myopathies, including those associated with medications and specific genetic conditions.
  • To review key findings in muscular dystrophies, Pompe disease, and myotonic disorders.

Main Methods:

  • Literature review of recent reports and studies on myopathies.
  • Discussion of specific myopathy categories including lipid storage, monoclonal gammopathy-associated, statin-related, toxic, immune-mediated, and genetic forms.
  • Focus on treatment-responsive conditions and emerging therapeutic data.

Main Results:

  • Identified treatable lipid storage myopathies associated with sertraline and ranolazine.
  • Discussed monoclonal gammopathy-associated myopathies, including a treatment-responsive glycogen storage form.
  • Reviewed statin-related muscle symptoms, toxic myopathies, immune-mediated necrotizing myopathy, and other autoimmune myopathies.
  • Covered muscular dystrophies (dystrophinopathies, limb-girdle, facioscapulohumeral), Pompe disease (enzyme replacement therapy), congenital myopathies, and myotonic disorders.

Conclusions:

  • Various myopathies, including drug-induced and genetic forms, are treatable.
  • Advances in understanding and treatment are ongoing for conditions like Pompe disease and muscular dystrophies.
  • This review synthesizes current knowledge on a spectrum of myopathies, emphasizing diagnostic and therapeutic progress.